Description #
This lecture begins with an introduction to and exploration of the general principals of antimicrobial agents, and the mechanisms and action of antimicrobial agents. We will examine microbial resistance and antimicrobial therapies. From there this lecture considers the selectivity of antimicrobial action, and the action of agents acting on bacterial cell walls. This lecture then considers the toxicity of penicillins, agents that alter plasma membrane integrity, and antimicrobials that affect nucleic acid metabolism and/or function. Students will be provided with an overview of DNA gyrase inhibitors, the inhibition of RNA polymerase, and the degradation of DNA. Finally this lecture will explore antimicrobials that inhibit protein synthesis, and antimicrobials acting as antimetabolites.
Learning Objectives #
Microbial resistance
Intrinsic and acquired
Possible mechanisms of antimicrobial resistance
Selectivity of Antimicrobial Action
Disinfectants/antiseptics versus antimicrobials
Agents acting on bacterial cell walls
Agents altering plasma membrane integrity
Antimicrobials affecting nucleic acid metabolism and/or function
Antimicrobials inhibiting protein synthesis
Antimicrobials acting as antimetabolites
Variability in Response to Drugs
Compliance and Gender
Drug disposition in the elderly
Drug Interactions
Pharmacology Of Antimicrobial Agents lecture by Dr. David Godin #
part 1
part 2
part 3
part 4
part 5
part 6
You can find lectures files here.